Rabbit Anti-LCAR- B38M Monoclonal Antibody (Clone 38-1A2), Alexa Fluor 647 (25 tests)

Description

38-1A2 is a specific antibody that binds precisely to two tandem VHH sequences of LCAR-B38M. These sequences are designed to target two epitopes of the B-cell maturation antigen (BCMA). BCMA is a protein expressed selectively by B-lineage cells, including both normal and malignant plasma cells in multiple myeloma. Ciltacabtagene autoleucel, also known as cilta-cel or Carvykti, is a gene-edited autologous CAR T-cell therapy. It utilizes LCAR and B38M to effectively recognize BCMA-positive cells.

Flow cytometric analysis of anti-LCAR-B38M CAR expression on human cell line Jurkat cells. Jurkat cells were transduced with lentivirus encoding LCAR-B38M CAR and cultured. 2×10⁵ cells were stained for the expression of Rabbit Anti-LCAR-B38M Monoclonal Antibody, Alexa Fluor 647 (Product No.212701, right panel). Non-transduced Jurkat cells were used as a control for gating of CAR expression (left panel).

Product Infomation

Preparation & Storage

• Store undiluted at 2-8°C.
• Avoid prolonged exposure to light.
• Avoid freeze/thaw cycle of the reagent.
• The monoclonal antibody was purified by Protein A.
• The antibody was conjugated with Alexa Fluor 647 under optimum conditions, and unincorporateddye was removed.