Anti-MSLN (M5 scFv) CAR ldiotype Antibody (Clone M5-D12), Alexa Fluor 647 (25 tests)

Description

The rabbit monoclonal antibody M5-D12 specifically binds to the scFv region of a M5-specific human monoclonal antibody (mAb, clone M5). Mesothelin, also known as MSLN, is a glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein, Because of its limited expression in normal tissues and its overexpression in several solid tumors such as ovarian cancer, breast cancer, colorectal cancer and pancreatic cancer, which is associated with a lower survival rate, it is an ideal target for tumor-specific therapy. The scFv region of M5 has been used to develop MSLN specific chimeric antigen receptor (CAR) T cells utilized in clinical trials.

Product Infomation

Preparation & Storage

• Store undiluted at 2-8°C.
• Avoid prolonged exposure to light.
• Avoid freeze/thaw cycle of the reagent.
• The monoclonal antibody was purified by Protein A.
• The antibody was conjugated with Alexa Fluor 647 under optimum conditions, and unincorporated dye was removed.